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KMID : 0624620180510070362
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BMB Reports
2018 Volume.51 No. 7 p.362 ~ p.367
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Protective effects of Tat-DJ-1 protein against streptozotocin-induced diabetes in a mice model
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Yeo Hyeon-Ji
Yeo Eun-Ji
Shin Min-Jea
Choi Yeon-Joo
Lee Chi-Hern
Kwon Hyeok-Yil
Kim Dae-Won
Eum Won-Sik
Choi Soo-Young
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Abstract
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A major feature of type 1 diabetes mellitus (T1DM) is hyperglycemia and dysfunction of pancreatic β-cells. In a previous study, we have shown that Tat-DJ-1 protein inhibits pancreatic RINm5F β-cell death caused by oxidative stress. In this study, we examined effects of Tat-DJ-1 protein on streptozotocin (STZ)-induced diabetic mice. Wild type (WT) Tat-DJ-1 protein transduced into pancreas where it markedly inhibited pancreatic β-cell destruction and regulated levels of serum parameters including insulin, alkaline phosphatase (ALP), and free fatty acid (FFA) secretion. In addition, transduced WT Tat-DJ-1 protein significantly inhibited the activation of NF-κB and MAPK (ERK and p38) expression as well as expression of COX-2 and iNOS in STZ exposed pancreas. In contrast, treatment with C106A mutant Tat-DJ-1 protein showed no protective effects. Collectively, our results indicate that WT Tat-DJ-1 protein can significantly ameliorate pancreatic tissues in STZ-induced diabetes in mice.
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KEYWORD
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Blood glucose, Diabetes mellitus, Insulin, Protein therapy, Tat-DJ-1
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